AOT/SOT for Lyme,Co-infection, Viruses

Antisense oligonucleotide therapy (AOT/SOT)


​In 1978, Paul Zamecnik and Mary Stephenson reported the first experiments on antisense mechanisms of gene silencing using short synthetic antisense oligonucleotides to inhibit replication of a rales sarcoma virus by binding and blocking the action of 35s RNA. In the following years, attention turned to the possible therapeutic applications of antisense technology. Since that time, six antisense treatments have been approved by the FDA.

SOT is a treatment for cancer, Lyme bacteria, co-infections, and other viruses.  Essentially SOT is the creation of a shutoff key” that precisely fits a chosen “lock” portion of a cancer cell or pathogen.  The “lock” is a specific section of DNA that normally controls an important function of the pathogen.  The “key” binds to the “lock” and blocks the function thus killing the pathogen.  After the cancer cell or pathogen dies the SOT compound is released and travels to the next target, thus fighting the cancer or infection 24/7 for months.


In other words, SOT works simply by shutting down the gene replication sequences of our target causing apoptosis (cell death) therefore eliminating the next life-cycle.  Once the life-cycle of the spirochete has been completed there are just simply no spirochetes left.  

SOT therapy is not FDA-approved, or being studied under an Investigational New Drug Application (IND), which is a clinical investigation plan, submitted and allowed to proceed by the FDA.

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Key Advantages of SOT

  • Highly specific therapy and will only work for the patient that is was made for.

  • SOT therapy uses miRNA's to only influence certain gene expressions not to change genetic structure.

  • Able to cross the blood brain barrier with ease.

  • SOT has a stealth characteristic (meaning it is unnoticed by the body’s RNase)

  • Remains active in the blood stream for approximately 14-26 weeks (maybe longer) per dose. 

  • SOT will work 24/7 and has no decreased efficacy with any concurrent technique except rarely chemotherapy and or radiation.

  • Can be used for cancer, Lyme, and co-infection therapy. 

How does SOT work?

SOT is a cutting edge treatment for infections, including numerous viruses and the bacteria the causes Lyme disease.  A confirmation of infection through recognized US labs within 6 months prior to ordering SOT is sufficient to start therapy. Blood is then drawn and sent to RGCC to prepare the SOT treatment. 

RGCC Laboratory located in Greece is a genetic laboratory which is capable of identifying the specific gene sequences of different targets such as cancer, Lyme and other viruses. We send a patient's blood to their lab and they identify the main genetic sequence (gene epitope) of our target genes. Once they identify the main genetic epitope of the target, they cross reference the gene sequences to an international database of genetics to ensure they have the proper sequences. RGCC created this unique fingerprinting technology so that we can ensure the success of this treatment. It creates a 98% specificity to our target genes such as the Lyme Spirochetes and it does not interfere with any other human cells. Once the replication genes (sense strand) are identified, the laboratory creates the anti-copy of the replication sequences of the translocation genes. The sense strand is the particular code of the genetics that creates replication in the cell. RGCC splices apart the sense strand and makes a complimentary copy of the DNA sequences that creates replication. This in turn creates an anti-sense therapy.  


Once they create the complimentary copy of the replication sequences, they surround this copy with a synthetic messenger RNA so that it has the ability to penetrate within the cell wall of our target. Once this mRNA sequence is created, they replicate this to 500 million to 1 billion copies of your unique SOT molecules. These molecules are delivered to our office where you receive your one dose IV treatment.  

Once you receive your SOT molecules, they are at work 24-hours a day,  seven days a week for up to six months inhibiting the replication cycle of your target spirochetes. 

The Lyme spirochetes have a life cycle of 80 days. It is the longest life cycle of any bacteria in science and it has one of the most complicated gene sequences that we study. One point of interest is to note that this treatment is not an immune treatment and it does not work through the immune activation system therefore there is very minimal side effects. SOT works simply by shutting down the gene replication sequences of our target therefore eliminating the next life cycle.  Once the life cycle of the spirochete has been completed there are just simply no spirochetes left.  

In summary, when the genetic sequence of a particular gene is known to be a causative gene of a particular disease, it is possible to synthesize a strand of nucleic acid (DNA, RNA or a chemical analogue) that will bend to the messenger RNA (MRNA) produced by that gene and effectively turning that gene “off”. This is called gene silencing therapy or apoptosis inducing therapy.


Isis Module 1 Animation How Antisense Drugs Work