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AOT/SOT for Lyme,Co-infection, Viruses

Antisense oligonucleotide therapy (AOT/SOT)


​What is SOT?

At LEDA Medical we use Sot for treatment of Lyme bacteria, co-infections, and other viruses.  Essentially SOT is the creation of a shutoff “key” that precisely fits a chosen “lock” portion of a cancer cell or pathogen.  The “lock” is a specific section of DNA that normally controls an important function of the pathogen.  The “key” binds to the “lock” and blocks the function thus killing the pathogen.  After the cancer cell or pathogen dies the SOT compound is released and travels to the next target, thus fighting the cancer or infection 24/7 for months.In other words, SOT works simply by shutting down the gene replication sequences of our target causing apoptosis (cell death) therefore eliminating the next life-cycle.  

SOT therapy is not FDA-approved, or being studied under an Investigational New Drug Application (IND), which is a clinical investigation plan, submitted and allowed to proceed by the FDA.

SOT Q.png

For LEDA Patients ONLY

SOT Q.png
Image of SOT antisense

Key Advantages of SOT

  • Highly specific therapy and will only work for the patient that is was made for.

  • SOT therapy uses miRNA's to only influence certain gene expressions not to change genetic structure.

  • Able to cross the blood brain barrier with ease.

  • SOT has a stealth characteristic (meaning it is unnoticed by the body’s RNase)

  • Remains active in the blood stream for approximately 14-26 weeks (maybe longer) per dose. 

  • SOT will work 24/7 and has no decreased efficacy with any concurrent technique except rarely chemotherapy and or radiation.

  • Can be used for cancer, Lyme, and co-infection therapy. 

What viruses and pathogens does it help with and do you treat in your office?


Leda Medical currently offers SOT for the below :

Borrelia mayonii – Borrelia burgdorferi – Borrelia garinii – Borrelia bissettii – Borrelia bavariensis – Borrelia miyamotoi – Candidatus Borrelia tachyglossi – Borrelia valaisiana – Borrelia afzelii – Borrelia finlandensis – Borrelia recurrentis – Bartonella henselae – Bartonella bacilliformis – Bartonella vinsonii – Bartonella quintana – Babesia microti – Babesia bigemina – Babesia divergens – Babesia duncani – Babesia bovis

The following viruses:
– EBV (Epstein Barr Virus)
– CMV (cytomegalovirus)
– Coxsackie virus (Types A & B)
– HHV1/HSV1 (oral herpes virus) – HHV2/HSV2 (genital herpes virus) – HHV6 (Types A & B) (human herpes virus 6)

* It is not recommended to treat the same infection with SOT more than 3 times in a 12 month period.

What tests are used for SOT?

We use a variety of testing to determine whether you are a possible candidate for SOT. You must have a positive lab result for a particular infection within the last 6 months.


What are the side effects?
Because it is derived from the patient’s own blood, the side effects are usually minimal. But may occur usually 2 weeks after administration. Patient may experience “Herx” like reactions, which include body aches, fatigue, headaches, fever and more.

How do I know if it’s working?

Clinical & Laboratory findings improve. This would require a discussion with your treating clinician.


What is the process?

Patients will have a blood draw done, in which their blood sample is collected and will be shipped to RGCC labs in Greece. It takes about 4 weeks to create an SOT. When created it will be shipped back to our office for patient administration. Patients will come in the office for an iv infusion which typically takes up to one hour.

How often should patients carry out a follow-up test?
It depends on your treatment plan provided by your clinician.

Research Study


Isis Module 1 Animation How Antisense Drugs Work

SOT Guidlines

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